This paper presents various therapeutic approaches, such as art/expressive therapy and animal therapy in working with children with autism spectrum disorder. Children with autism spectrum disorder process information differently and need more help in understanding and developing many other skills. The aim of this paper is to give a theoretical overview of autism spectrum disorders and art/expressive therapeutic approaches and therapy with dogs and horses, and the results of empirical research on the application of these therapeutic approaches in working with children with autism spectrum disorder. Art as a major component of art/expressive therapies encourages children to explore and express themselves. Thus in the works we can see drawing, making music or movement, dramatization or use of literature through which children with autism spectrum disorder learn about their feelings, deal with different situations and encourage them to explore social interactions. Animal-assisted therapeutic approaches with children with autism spectrum disorder have also shown positive results such as a reduction in anxiety, stress and discomfort, and success in making new social contacts. An environment with pets such as a therapy dog or structured contact with a therapy horse can be great approaches in encouraging development with autism spectrum disorder. The presented empirical research shows an individual therapeutic approach in working with children with autism spectrum disorder and their positive impact on the development of these children.